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The best performance for detecting LOS was obtained with logistic regression, using the feature set including visibility graph features, with AUROC of 87.7% during the six hours preceding the start of antibiotics, and with predictive potential (AUROC above 70%) as early as 42h before start of antibiotics.
These results demonstrate the usefulness of introducing visibility graph indexes in HRV analysis for sepsis prediction in newborns.
The method proposed the possibility of non-invasive, real-time monitoring of risk of LOS in a NICU setting.
The method proposed the possibility of non-invasive, real-time monitoring of risk of LOS in a NICU setting.In recent years, deep learning methods have received more attention in epithelial-stroma (ES) classification tasks in histopathological images. Traditional deep learning methods assume that the training and test data have the same distribution, an assumption that is seldom satisfied due to complex imaging procedures. Unsupervised domain adaptation (UDA) transfers knowledge from a labelled source domain to a completely unlabeled target domain, and is more suitable for ES classification tasks to avoid tedious annotation. However, existing UDA methods for this task ignore the semantic alignment across domains. In this paper, we propose a Curriculum Feature Alignment Network (CFAN) to progressively align discriminative features across domains through selecting effective samples from the target domain and minimizing cross-domain intra-class differences. Specifically, we developed the Curriculum Transfer Strategy (CTS) and Adaptive Centroid Alignment (ACA) steps to train our model iteratively. We validated the method using three independent public ES datasets, and experimental results demonstrate that our method achieves better performance in ES classification compared with commonly used deep learning methods and existing deep domain adaptation methods.independent public ES datasets, and experimental results demonstrate that our method achieves better performance in ES classification compared with commonly used deep learning methods and existing deep domain adaptation methods.We developed a wearable watch-based device to provide noninvasive, cuff-less blood pressure (BP) estimation in an at-home setting. The watch measures single-lead electrocardiogram (ECG), tri-axial seismocardiogram (SCG), and multi-wavelength photoplethysmogram (PPG) signals to compute the pulse transit time (PTT), allowing for BP estimation. We sent our custom watch device and an oscillometric BP cuff home with 21 healthy subjects, and captured the natural variability in BP over the course of a 24-hour period. After calibration, our Pearson correlation coefficient (PCC) of 0.69 and root-mean-square-error (RMSE) of 2.72 mmHg suggest that noninvasive PTT measurements correlate with around-the-clock BP. Using a novel two-point calibration method, we achieved a RMSE of 3.86 mmHg. We further demonstrated the potential of a semi-globalized adaptive model to reduce calibration requirements. This is, to the best of our knowledge, the first time that BP has been comprehensively estimated noninvasively using PTT in an at-home setting. We showed a more convenient method for obtaining ambulatory BP than through the use of the standard oscillometric cuff. selleck kinase inhibitor We presented new calibration methods for BP estimation using fewer calibration points that are more practical for a real-world scenario. A custom watch (SeismoWatch) capable of taking multiple BP measurements enables reliable remote monitoring of daily BP and paves the way towards convenient hypertension screening and management, which can potentially reduce hospitalizations and improve quality of life.Recent techniques built on generative adversarial networks (GANs), such as cycle-consistent GANs, are able to learn mappings among different domains built from unpaired data sets, through min-max optimization games between generators and discriminators. However, it remains challenging to stabilize the training process and thus cyclic models fall into mode collapse accompanied by the success of discriminator. To address this problem, we propose an novel Bayesian cyclic model and an integrated cyclic framework for interdomain mappings. The proposed method motivated by Bayesian GAN explores the full posteriors of cyclic model via sampling latent variables and optimizes the model with maximum a posteriori (MAP) estimation. Hence, we name it Bayesian CycleGAN. In addition, original CycleGAN cannot generate diversified results. But it is feasible for Bayesian framework to diversify generated images by replacing restricted latent variables in inference process. We evaluate the proposed Bayesian CycleGAN on multiple benchmark data sets, including Cityscapes, Maps, and Monet2photo. The proposed method improve the per-pixel accuracy by 15% for the Cityscapes semantic segmentation task within origin framework and improve 20% within the proposed integrated framework, showing better resilience to imbalance confrontation. The diversified results of Monet2Photo style transfer also demonstrate its superiority over original cyclic model. We provide codes for all of our experiments in https//github.com/ranery/Bayesian-CycleGAN.The aim of unsupervised domain adaptation is to leverage the knowledge in a labeled (source) domain to improve a model's learning performance with an unlabeled (target) domain--the basic strategy being to mitigate the effects of discrepancies between the two distributions. Most existing algorithms can only handle unsupervised closed set domain adaptation (UCSDA), i.e., where the source and target domains are assumed to share the same label set. In this article, we target a more challenging but realistic setting unsupervised open set domain adaptation (UOSDA), where the target domain has unknown classes that are not found in the source domain. This is the first study to provide learning bound for open set domain adaptation, which we do by theoretically investigating the risk of the target classifier on unknown classes. The proposed learning bound has a special term, namely, open set difference, which reflects the risk of the target classifier on unknown classes. Furthermore, we present a novel and theoretically guided unsupervised algorithm for open set domain adaptation, called distribution alignment with open difference (DAOD), which is based on regularizing this open set difference bound.