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Multivariate logistic regression showed that patients with high lactic acid, coagulation dysfunction, high levels of PCT, CRP, IL-6, TNF-α, CK-MB, and cTnI, but low H19 expression had an increased risk of sepsis.
Peripheral blood H19 may be used for early diagnosis, clinical assessment, and prognosis of sepsis.
Peripheral blood H19 may be used for early diagnosis, clinical assessment, and prognosis of sepsis.
This study was designed to explore the feasibility and effectiveness of patient-centered care (PCC) on basis of guidelines of Joint Commission on Accreditation of Healthcare Organizations (JCI) in patients with acute subarachnoid hemorrhage (SAH).
A total of 180 SAH patients who received treatment in our hospital were selected as prospective research objects, and were divided into a study group (n=90) and a control group (n=90) by convenience sampling. Patients in the control group received conventional SAH-targeted care, and patients in the study group were additionally nursed with PCC on the basis of conventional SAH-targeted care. The general indicators, including Mini-Mental State Exam (MMSE) scores before and after intervention, activities of daily living (ADL), mental state, general self-efficacy scale (GSES), health knowledge, and incidence of complications were compared between the two groups.
The length of hospital stay, the time in bed, and the expenses of hospitalization in the study group were lower than those of the control group (
<0.05). The scores of MMSE, ADL, GSES, and health knowledge in the study group were higher than those in the control group (
<0.05), and the scores of each dimension of Symptom Checklist-90 (SCL-90) and the incidence of complications in the study group were lower than those in the control group (
<0.05).
PCC for SAH patients based on the guidelines of JCI can not only improve the outcomes, cognitive function, self-efficacy, negative emotions and ADL of patients, but also help enhance their awareness of the disease and reduce the incidence of complications.
PCC for SAH patients based on the guidelines of JCI can not only improve the outcomes, cognitive function, self-efficacy, negative emotions and ADL of patients, but also help enhance their awareness of the disease and reduce the incidence of complications.
To analyze the influences of Xuebijing injection combined with cefoperazone sodium and sulbactam sodium (CSSS) in the treatment of hepatitis B-induced liver cirrhosis (HBLC) complicated by spontaneous bacterial peritonitis (SBP) with respect to tumor necrosis factor-α (TNF-α), interleukin-18 (IL-18), interleukin-6 (IL-6), and hepatic function.
A total of 98 patients with HBLC complicated by SBP admitted to our hospital were selected and divided into the control group (CON, n=49) and the observation group (OBG, n=49) in accordance with the therapeutic methods. The clinical data of the patients were retrospectively analyzed. The CON was treated with CSSS, while the OBG was treated with Xuebijing injection combined with CSSS. The time of symptomatic improvement and changes of serum inflammatory factors and indices of intestinal mucosal barrier damage and hepatic function were compared between the two groups before and after treatment.
The time of symptomatic improvement in the OBG was shorter than that in the CON (
< 0.05). After treatment, IL-6, IL-18, TNF-α, urinary L/M, D-lactic acid, DAO, total bilirubin, ALT, and AST in the OBG were lower than those in the CON (
< 0.05).
Xuebijing injection combined with CSSS is conducive to improving the inflammatory responses of the body, intestinal tract barrier function, and hepatic function, showing satisfactory efficacy in the treatment of HBLC complicated by SBP.
Xuebijing injection combined with CSSS is conducive to improving the inflammatory responses of the body, intestinal tract barrier function, and hepatic function, showing satisfactory efficacy in the treatment of HBLC complicated by SBP.
This study aims to explore the therapeutic effects of bevacizumab combined with oxaliplatin on patients with malignant pleural effusion of lung cancer.
A total of 109 patients with malignant pleural effusion of lung cancer admitted to our hospital from March 2015 to April 2017 were selected as research objects. Among them, 59 patients treated with bevacizumab combined with oxaliplatin intrathoracic injection were enrolled in the observation group, and another 50 patients treated with oxaliplatin intrathoracic injection were enrolled in the regular group. Clinical efficacy and safety of the two groups were compared, as well as the expression of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor (VEGFR) and tumor markers before and after treatment. The two groups of patients were followed up for 3 years to compare their prognosis, survival and quality of life.
The cure rate of the observation group was higher than that of the regular group (
< 0.05), but there was no difference in the incidence of adverse reactions (
> 0.05). After treatment, VEGF, VEGFR and tumor markers in the observation group were significantly lower than those in the regular group (
< 0.05), while the survival rate and quality of life of the observation group were significantly higher than those in the regular group (
< 0.05).
Bevacizumab combined with oxaliplatin intrathoracic injection is effective in treating malignant pleural effusion of lung cancer.
Bevacizumab combined with oxaliplatin intrathoracic injection is effective in treating malignant pleural effusion of lung cancer.
To investigate the efficacy of systemic care combined with thymopentin and 2HRZE/4HR in the treatment of primary tuberculosis.
The clinical data of 93 patients with primary tuberculosis were retrospectively collected and divided into two groups based on the intervention method. Compound 19 inhibitor Group A (n=46) was treated only with 2HRZE/4HR, and group B (n=47) was treated with the 2HRZE/4HR combined with thymopentin. Meanwhile, both groups received systematic care. The lesion absorption rate, sputum conversion rate (SCR), T lymphocyte subpopulation count, immunoglobulin level, lung function index, changes in sputum supernatant levels of cytokines before and after treatment, and the occurrence of adverse reactions were compared.
Group B exhibited higher complete absorption rate of foci and lower basic absorption rate than group A (
< 0.05). The SCRs of group B after 2, 4 and 6 months of intervention were higher than those of group A (
< 0.05). Compared with group A, group B had lower CD8
level and higher CD4
and CD3
levels (
< 0.