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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized by their focus on practical aspects of design that include recruitment and consent, adherence and the use of standard equipment.
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프라그마틱 무료슬롯 that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be valid and lessen the chance of bias, is also necessary. Too much heterogeneity, however can result in problems with the design of the trial.
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Pragmatic Play offers not only mobile-friendly slot machines, but also tables games and live casinos. The company is licensed and is regulated by various regulatory bodies, including the Malta Gaming Authority and UK Gambling Commission. Its games are backed by the latest encryption technology and the security team is always ready to assist players solve any issues they might face.
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Legality
Pragmatic Play is renowned for its top-quality games and for providing a superior user experience. Its software is designed to work on mobile devices and is compatible with multiple languages. Despite its infancy it has established itself as a top gaming platform for casinos. Wolves is one of its latest releases which is a five-reel slot machine that has a high RTP and impressive graphics. Its other notable titles are Wolf Gold and Chilli Heat.
The goal of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. Usually, they are requested by practitioners and policymakers to help inform their decisions. They also provide a useful way to identify the causal relationship between an intervention and its outcomes. However, they shouldn't be used to substitute for explanation studies.
The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which prove the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the characteristics of a practical trial that include the recruitment process, the design and delivery of the intervention, and the follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatism. However, it is important to note that the majority of these trials were conducted in primary care settings.