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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are typically focused on the practical aspects of the study design, including recruitment and consent as well as adherence to the use of commonly available equipment.
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you could check here that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity, and it also reduces bias in the results. However too much heterogeneity could lead to problems with the design of the trial.
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Pragmatic trials aim to mimic real-world situations and have the highest external validity. Usually, they are ordered by policymakers and practitioners to help guide their decisions. They can also be used to assess the cause-effect relationship of an intervention and its results. However, they shouldn't be used to substitute for the use of explanation studies.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the elements of a practical study which includes recruitment, design, implementation of the intervention, and follow-up.
There is a growing increase in the number pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to remember, however, that the majority of these studies were conducted in primary-care settings.