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Our results showed that circ-FBXW7 was decreased in oxaliplatin-resistant CRC patients and cells. circ-FBXW7 was secreted by circ-FBXW7-transfected FHC cells and could be transferred to resistant CRC cells through the exosome secretion. Subsequently, in vitro and in vivo studies demonstrated exosomal circ-FBXW7 led resistant cells sensitive to oxaliplatin, increased the oxaliplatin-induced apoptosis, inhibited oxaliplatin-induced epithelial-mesenchymal transition, and suppressed oxaliplatin efflux. miR-18b-5p was increased in oxaliplatin-resistant CRC patients and cells and was confirmed to be a target of circ-FBXW7. Immediately, the rescue assay showed exosome-mediated transfer of circ-FBXW7 enhanced oxaliplatin sensitivity by binding to miR-18b-5p in vitro and in vivo. [https://www.selleckchem.com/products/slf1081851-hydrochloride.html SLF1081851 datasheet] To conclude, the circ-FBXW7 delivery by exosomes could ameliorate chemoresistance to oxaliplatin in CRC by directly binding to miR-128-3p, suggesting a promising therapeutic strategy for oxaliplatin-resistant CRC patients.A Pd-catalyzed regioselective C-H alkenylation of allylic alcohols with electron-deficient alkenes has been developed. The key to success is the introduction of bidentately coordinating phenanthroline directing group, which enables the otherwise challenging and regioselective C-H activation at the proximal alkenyl C-H bonds over the conceivably competitive allylic C-O bond activation. The same Pd/phenanthroline system is efficient for the C-H alkynylation of allylic alcohols with alkynyl bromides.A visible light-induced radical cascade reaction of 2-alkynylarylethers with sodium sulfinates was established for the synthesis of sulfonyl-functionalized dihydrobenzofurans, and an intramolecular 1,5-hydrogen atom transfer was involved in this transformation. This process provided an efficient and convenient C-C formation protocol for the construction of a dihydrobenzofuran ring. Various substituents on 2-alkynylarylethers and sodium sulfinates were tolerated in the reaction, and the corresponding products were obtained in moderate to good yields.A novel process involving Grignard-reagent-promoted desulfonylation/intramolecular coupling of readily available α-fluoro-α,β-unsaturated-(2-pyridyl)sulfones was realized that provided a series of polysubstituted 2-(1-fluorovinyl)pyridines in good yields. The intrinsic coordination between pyridine and Mg(II) along with the "negative fluorine effect" of the substrates should play the key role for the smooth transformation in the absence of transition-metal catalysts.A total of 115 aryl amides were synthesized and screened for vapor repellency against the Orlando (OR) strain of Aedes aegypti mosquitoes. Of these compounds, 29 had 1 h repellency EC50 values comparable to or better than N,N-diethyl-meta-toluamide (DEET, 1 h EC50 value of 35 μg/cm2), with 2,2,3,3,3-pentafluoro-N-(4-fluorophenyl)propenamide (53) and 2,2,3,3,4,4,4-heptafluoro-N-(3,4,5-trifluorophenyl)butanamide (101) exhibiting the most potent EC50 values of 4.5 and 2.9 μg/cm2, respectively. The cross-resistance of select, highly potent, derivatives against the pyrethroid-resistant Puerto Rico (PR) strain of A. aegypti was also investigated, and little to no resistance was observed. When synergized with 1R-trans-permethrinic acid (TFA), compound 101 had a 1 h EC50 value 6 times lower than metofluthrin against OR and 40 times lower against PR mosquitoes. Additionally, preliminary mammalian oral toxicity was screened for compounds 69 and 101, and both exhibited LD50 values of &gt;2000 mg/kg. The structure-activity relationship analysis, which guided the synthesis of these derivatives, is given, and key trends are highlighted to inform future analogue design.Facile preparation of poly(vinylidene fluoride) (PVDF) homopolymer nanoparticles (NPs) with monodispersed size distribution and predominant ferroelectric phases was done in an interfacial nonsolvent (water/methanol)-solvent (dimethylformamide (DMF))-polymer (PVDF) ternary system using two interfacial nanoassembly methods. First, a fluidic liquid-liquid interface consisting of two miscible solvents was created by introducing nonsolvent (water) under the PVDF solution. After the interface was created, the interface moved up to the DMF phase direction; PVDF NPs were produced through nonsolvent-induced phase separation. As the water content decreased in the nonsolvent by mixing with methanol, PVDF structures changed from nanoparticles with 252 nm average diameter (PVDF NP-1) to a porous membrane through membrane-wrapped NPs. The phenomena were found to be related to the mutual affinity of solvent, nonsolvent, and PVDF. When an additional external force was introduced to the water-DMF-PVDF system through magnetic stirring (reprecipitation method), smaller PVDF NPs with 61.4 nm diameter were obtained (PVDF NP-2). Both the as-prepared PVDF NPs were demonstrated with the predominant ferroelectric (electroactive (EA)) phase up to 97-98% among crystalline phases, which is apparently the highest value ever reported for PVDF homopolymer NPs. It is noteworthy that PVDF NP-2 showed a higher β phase ratio than that of PVDF NP-1, as proved using Fourier transform infrared (FT-IR) spectroscopy. Also, differential scanning calorimetry (DSC) and X-ray diffraction (XRD) measurements revealed that PVDF NP-1 exhibited higher crystallinity and that PVDF NP-2 underwent a well-separated two-step phase transition under heating. Results suggest that controlling interface formation with DMF and water plays a crucial role in manipulating ferroelectric PVDF nanostructures in terms of crystallinity and the ferroelectric β phase-to-γ phase ratio.Electrochemical-induced transfer hydrogenation (TH) of N-heteroaromatic to construct biologically active functional molecule is an appealing and yet challenging task. We report herein the first selective transfer hydrogenation of imidazopyridine derivatives with secondary amines as the hydrogen donors under electrochemical conditions. The successful conversion of cathode transfer hydrogenation depends on the solvation effect. Importantly, such electrochemical-induced transfer hydrogenation can be easily amplified with excellent efficiency.